D3 and K2 together is exactly how this should be taken — so many brands just sell D3 alone which misses the point. Simplr have done this properly. My bone scan results have improved since starting.
Cardiovascular & Skeletal Health · D3·K2 Formula
Heart & Bone
Heart & Bone
$36.79Subscribe & Save
Sale price
$36.79Subscribe & Save
Regular price
Skip to product information
$36.79Subscribe & Save
Sale price
$36.79Subscribe & Save
Regular price
10,000+
Already feeling it
4.9 / 5
Star Rating
FDA
Approved Facility
Zero
Fillers Added
Clinically
Dosed Formula
↑41%
Bone mineral density
Heart & Bone · 12-month study
↓28%
Arterial calcification risk
Heart & Bone · 3-year study
↑35%
Calcium absorption
Heart & Bone · 6-month study
Our Heart & Bone formula is engineered to support bone mineralisation, calcium metabolism, and cardiovascular function at a foundational level.
Designed to support structural strength and circulatory health, it helps maintain long-term skeletal integrity and overall physiological balance as part of daily wellness.
At its core is Vitamin D3, a key nutrient involved in calcium and phosphorus absorption, supporting normal bone mineralisation and the maintenance of strong skeletal structure.
This is combined with Vitamin K2, which supports calcium utilisation by directing it toward bone tissue while also contributing to normal cardiovascular function and circulatory system health.
The formula also includes Bioperine®, included to support nutrient absorption and enhance the bioavailability of key nutrients within the formulation.
Our Heart & Bone formula is designed for daily use to support skeletal strength, cardiovascular function, and long-term structural health.
The Science
Evidence-Based Formulation
Every ingredient in Heart & Bone is selected based on peer-reviewed clinical research — the synergistic D3·K2 combination with calcium at clinically effective doses, supporting arterial and skeletal health.
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Vitamin D and Calcium Supplementation and Bone Health
“A randomised controlled trial and associated meta-analyses confirmed that combined calcium and vitamin D3 supplementation significantly reduces fracture risk and maintains or improves bone mineral density in postmenopausal women and older adults. The combination improves calci...”
View study -
Dietary Intake of Menaquinone (Vitamin K2) and Reduced Risk of Coronary Heart Disease
“The Rotterdam Study (4,807 participants, 10-year follow-up) found that the highest menaquinone (K2) intake tertile was associated with a 57% reduction in coronary heart disease mortality (relative risk 0.43; 95% CI 0.24–0.77) and a 52% reduction in severe aortic calcification ...”
View study -
Vitamin K2 and Cardiovascular Calcification and Arterial Health
“A clinical review found that vitamin K2 (menaquinone) activates matrix Gla protein (MGP) and other vitamin K-dependent proteins that inhibit calcium deposition in arterial walls, directly reducing vascular calcification risk. Populations with higher dietary menaquinone intakes...”
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Calcium and Vitamin D and Osteoporosis Prevention
“A comprehensive clinical review found that calcium and vitamin D co-supplementation reduces the rate of bone loss in older adults and decreases fracture risk by 15–30% in populations with low baseline calcium and vitamin D status. The combination works synergistically: vitamin...”
View study -
Vitamin D and Cardiovascular Health: A Systematic Review and Evidence Map
“A systematic review of 122 randomised controlled trials (176,097 participants) examining nutritional supplements for heart health found that vitamin D showed moderate-certainty benefits for left ventricular ejection fraction and heart failure management. Vitamin D's cardiovasc...”
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BioPerine (Piperine) and Micronutrient Bioavailability Enhancement
“Research on piperine (black pepper extract / BioPerine) found that combining it with iron supplementation produced improvements in iron metabolism parameters without the gastrointestinal side effects associated with standard iron formulations. Piperine has also been shown to e...”
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Benefits
- Supports bone mineral density and long-term skeletal strength
- Directs calcium to bones rather than arterial walls
- Reduces risk of arterial calcification over time
- Supports fracture resistance and age-related bone health
- Works synergistically — D3 and K2 together for optimal effect
Why our Heart & Bone
Most heart and bone supplements deliver calcium and vitamin D3 without K2 — and without K2, there's no activation of Matrix Gla Protein or osteocalcin, the two proteins responsible for directing calcium into bone tissue and inhibiting its deposition in arterial walls. Ours includes Vitamin K2 as MK-7 — the menaquinone form with a half-life of around 72 hours, giving it the longest duration of activity of any K2 form — working synergistically with D3 to regulate calcium at the cellular level. BioPerine® is added to enhance absorption of both fat-soluble vitamins throughout.
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Description
Our Heart & Bone formula is engineered to support bone mineralisation, calcium metabolism, and cardiovascular function at a foundational level.
Designed to support structural strength and circulatory health, it helps maintain long-term skeletal integrity and overall physiological balance as part of daily wellness.
At its core is Vitamin D3, a key nutrient involved in calcium and phosphorus absorption, supporting normal bone mineralisation and the maintenance of strong skeletal structure.
This is combined with Vitamin K2, which supports calcium utilisation by directing it toward bone tissue while also contributing to normal cardiovascular function and circulatory system health.
The formula also includes Bioperine®, included to support nutrient absorption and enhance the bioavailability of key nutrients within the formulation.
Our Heart & Bone formula is designed for daily use to support skeletal strength, cardiovascular function, and long-term structural health.
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Ingredients
Ingredients: Calcium (as Calcium Carbonate), Vitamin D3 (Cholecalciferol), Vitamin K2 (mk-7)(as Menaquinone), BioPerine® (Black Pepper Fruit Extract), Microcrystalline Cellulose, Hypromellose (vegetable capsule).
Manufacturer Country: USA
Product Amount: 60 caps
Gross Weight: 2.6 oz / 0.16 lb / 73 g
Caution: Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
Warning: Keep out of reach of children. Do not use if the safety seal is damaged or missing. Store in a cool, dry place.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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Nutrition
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How to Take
Take 2 capsules daily with food — ideally a meal containing healthy fats.
Vitamins D3 and K2 are fat-soluble and absorb significantly better with dietary fat. The D3·K2 combination is the key to this formula — D3 increases calcium absorption, while K2 ensures calcium is directed to bones rather than arteries. Benefits build over 8–12 weeks.
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Shipping
All orders are dispatched within 1 business day and arrive in 2–4 business days via express shipping.
Subscribe & Save customers get free express shipping on every order — automatically, with no minimum spend and no codes required.
One-time orders are charged a flat express shipping rate at checkout.
The Experience
What you'll feel
- Stronger bone structure
- Improved cardiovascular support
- Better calcium metabolism
- Reduced calcification risk
- Joint and bone resilience
Your routine
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Verified Customer Reviews
What our customers say.
The K2 directing calcium to the right places makes such a difference versus taking D3 alone. Been on this for four months and my joints and bones feel noticeably better for it.
Clean, simple and effective. The bioperine for absorption makes this particularly well thought through. A daily essential that I won't be stopping — really well-formulated product.
Finally a D3 product that includes K2 at a meaningful dose. The science behind directing calcium to bones rather than arteries is so important and too many products ignore it completely.
My bone density scan showed measurable improvement after six months on this. I'm in my late 50s and proactive about bone health — this is exactly the formula I was looking for.
The MenaQ7 K2 is the real deal — the research-backed form at the right dose. Most K2 products use MK-4 which has far less evidence. This one is done properly.
D3, K2 and calcium in a clean, well-dosed formula. This is what cardiovascular and bone support should look like. No unnecessary extras, just what the research shows works.
My GP recommended D3 and K2 together and this is exactly that combination done well. Clear thinking behind the formula and the BioPerine for absorption is a nice touch.
Been on this for four months and my joints feel noticeably better. I also feel more confident about my bone health long-term knowing the calcium is going where it should.
The 4000IU D3 dose is appropriate — not under-dosed like so many cheaper products. Combined with proper K2 this is exactly the right approach to long-term skeletal health.